SOURCE

<div id="hd">header</div> 
  <div id="middle">
    <div id="inside">middle</div>
  </div>
  <div id="left">left</div>
  <div id="right">right</div>
  <div id="footer">footer</div>

#hd{
    height:50px;
    background: #666;
    text-align: center;
}
#middle{
    float:left;
    width:100%;/*左栏上去到第一行*/     
    height:100px;
    background:blue;
}
#left{
    float:left;
    width:180px;
    height:100px;
    margin-left:-100%;
    background:#0c9;
}
#right{
    float:left;
    width:200px;
    height:100px;
    margin-left:-200px;
    background:#0c9;
}

/*给内部div添加margin，把内容放到中间栏，其实整个背景还是100%*/ 
#inside{
    margin:0 200px 0 180px;
    height:100px;
}
#footer{  
   clear:both; /*记得清楚浮动*/  
   height:50px;     
   background: #666;    
   text-align: center; 
}