SOURCE

var isSupportFontFamily = function (fontFamily) {
    if (typeof fontFamily != 'string') {
        return false;
    }

    var defaultFontFamily = 'Arial';
    if (fontFamily.toLowerCase() == defaultFontFamily.toLowerCase()) {
        return true;
    }

    var defaultLetter = 'a';
    var defaultFontSize = 100;

    // 使用该字体绘制的canvas
    var width = 100, height = 100;
    var canvas = document.createElement('canvas');
    var context = canvas.getContext('2d');
    canvas.width = width;
    canvas.height = height;
    // 全局一致的绘制设定
    context.textAlign = 'center';
    context.fillStyle = 'black';
    context.textBaseline = 'middle';
    var getFontData = function (fontFamily) {
        // 清除
        context.clearRect(0, 0, width, height);
        // 设置字体
        context.font = defaultFontSize + 'px ' + fontFamily + ', ' + defaultFontFamily;
        context.fillText(defaultLetter, width / 2, height / 2);

        var data = context.getImageData(0, 0, width, height).data;

        return [].slice.call(data).filter(function(value) {
            return value != 0;
        });
    };

    return getFontData(defaultFontFamily).join('') !== getFontData(fontFamily).join('');
};
// isSupportFontFamily方法参见页面源代码
// 下面是演示代码
var eleSelect = document.getElementById('select');
var eleTarget = document.getElementById('target');
var dataFont = {"windows":[{"ch":"宋体","en":"SimSun"},{"ch":"黑体","en":"SimHei"},{"ch":"微软雅黑","en":"Microsoft Yahei"},{"ch":"微软正黑体","en":"Microsoft JhengHei"},{"ch":"楷体","en":"KaiTi"},{"ch":"新宋体","en":"NSimSun"},{"ch":"仿宋","en":"FangSong"}],"OS X":[{"ch":"苹方","en":"PingFang SC"},{"ch":"华文黑体","en":"STHeiti"},{"ch":"华文楷体","en":"STKaiti"},{"ch":"华文宋体","en":"STSong"},{"ch":"华文仿宋","en":"STFangsong"},{"ch":"华文中宋","en":"STZhongsong"},{"ch":"华文琥珀","en":"STHupo"},{"ch":"华文新魏","en":"STXinwei"},{"ch":"华文隶书","en":"STLiti"},{"ch":"华文行楷","en":"STXingkai"},{"ch":"冬青黑体简","en":"Hiragino Sans GB"},{"ch":"兰亭黑-简","en":"Lantinghei SC"},{"ch":"翩翩体-简","en":"Hanzipen SC"},{"ch":"手札体-简","en":"Hannotate SC"},{"ch":"宋体-简","en":"Songti SC"},{"ch":"娃娃体-简","en":"Wawati SC"},{"ch":"魏碑-简","en":"Weibei SC"},{"ch":"行楷-简","en":"Xingkai SC"},{"ch":"雅痞-简","en":"Yapi SC"},{"ch":"圆体-简","en":"Yuanti SC"}],"office":[{"ch":"幼圆","en":"YouYuan"},{"ch":"隶书","en":"LiSu"},{"ch":"华文细黑","en":"STXihei"},{"ch":"华文楷体","en":"STKaiti"},{"ch":"华文宋体","en":"STSong"},{"ch":"华文仿宋","en":"STFangsong"},{"ch":"华文中宋","en":"STZhongsong"},{"ch":"华文彩云","en":"STCaiyun"},{"ch":"华文琥珀","en":"STHupo"},{"ch":"华文新魏","en":"STXinwei"},{"ch":"华文隶书","en":"STLiti"},{"ch":"华文行楷","en":"STXingkai"},{"ch":"方正舒体","en":"FZShuTi"},{"ch":"方正姚体","en":"FZYaoti"}],"open":[{"ch":"思源黑体","en":"Source Han Sans CN"},{"ch":"思源宋体","en":"Source Han Serif SC"},{"ch":"文泉驿微米黑","en":"WenQuanYi Micro Hei"}],"hanyi":[{"ch":"汉仪旗黑","en":"HYQihei 40S"},{"ch":"汉仪旗黑","en":"HYQihei 50S"},{"ch":"汉仪旗黑","en":"HYQihei 60S"},{"ch":"汉仪大宋简","en":"HYDaSongJ"},{"ch":"汉仪楷体","en":"HYKaiti"},{"ch":"汉仪家书简","en":"HYJiaShuJ"},{"ch":"汉仪PP体简","en":"HYPPTiJ"},{"ch":"汉仪乐喵体简","en":"HYLeMiaoTi"},{"ch":"汉仪小麦体","en":"HYXiaoMaiTiJ"},{"ch":"汉仪程行体","en":"HYChengXingJ"},{"ch":"汉仪黑荔枝","en":"HYHeiLiZhiTiJ"},{"ch":"汉仪雅酷黑W","en":"HYYaKuHeiW"},{"ch":"汉仪大黑简","en":"HYDaHeiJ"},{"ch":"汉仪尚魏手书W","en":"HYShangWeiShouShuW"}],"fangzheng":[{"ch":"方正粗雅宋简体","en":"FZYaSongS-B-GB"},{"ch":"方正报宋简体","en":"FZBaoSong-Z04S"},{"ch":"方正粗圆简体","en":"FZCuYuan-M03S"},{"ch":"方正大标宋简体","en":"FZDaBiaoSong-B06S"},{"ch":"方正大黑简体","en":"FZDaHei-B02S"},{"ch":"方正仿宋简体","en":"FZFangSong-Z02S"},{"ch":"方正黑体简体","en":"FZHei-B01S"},{"ch":"方正琥珀简体","en":"FZHuPo-M04S"},{"ch":"方正楷体简体","en":"FZKai-Z03S"},{"ch":"方正隶变简体","en":"FZLiBian-S02S"},{"ch":"方正隶书简体","en":"FZLiShu-S01S"},{"ch":"方正美黑简体","en":"FZMeiHei-M07S"},{"ch":"方正书宋简体","en":"FZShuSong-Z01S"},{"ch":"方正舒体简体","en":"FZShuTi-S05S"},{"ch":"方正水柱简体","en":"FZShuiZhu-M08S"},{"ch":"方正宋黑简体","en":"FZSongHei-B07S"},{"ch":"方正宋三简体","en":"FZSong"},{"ch":"方正魏碑简体","en":"FZWeiBei-S03S"},{"ch":"方正细等线简体","en":"FZXiDengXian-Z06S"},{"ch":"方正细黑一简体","en":"FZXiHei I-Z08S"},{"ch":"方正细圆简体","en":"FZXiYuan-M01S"},{"ch":"方正小标宋简体","en":"FZXiaoBiaoSong-B05S"},{"ch":"方正行楷简体","en":"FZXingKai-S04S"},{"ch":"方正姚体简体","en":"FZYaoTi-M06S"},{"ch":"方正中等线简体","en":"FZZhongDengXian-Z07S"},{"ch":"方正准圆简体","en":"FZZhunYuan-M02S"},{"ch":"方正综艺简体","en":"FZZongYi-M05S"},{"ch":"方正彩云简体","en":"FZCaiYun-M09S"},{"ch":"方正隶二简体","en":"FZLiShu II-S06S"},{"ch":"方正康体简体","en":"FZKangTi-S07S"},{"ch":"方正超粗黑简体","en":"FZChaoCuHei-M10S"},{"ch":"方正新报宋简体","en":"FZNew BaoSong-Z12S"},{"ch":"方正新舒体简体","en":"FZNew ShuTi-S08S"},{"ch":"方正黄草简体","en":"FZHuangCao-S09S"},{"ch":"方正少儿简体","en":"FZShaoEr-M11S"},{"ch":"方正稚艺简体","en":"FZZhiYi-M12S"},{"ch":"方正细珊瑚简体","en":"FZXiShanHu-M13S"},{"ch":"方正粗宋简体","en":"FZCuSong-B09S"},{"ch":"方正平和简体","en":"FZPingHe-S11S"},{"ch":"方正华隶简体","en":"FZHuaLi-M14S"},{"ch":"方正瘦金书简体","en":"FZShouJinShu-S10S"},{"ch":"方正细倩简体","en":"FZXiQian-M15S"},{"ch":"方正中倩简体","en":"FZZhongQian-M16S"},{"ch":"方正粗倩简体","en":"FZCuQian-M17S"},{"ch":"方正胖娃简体","en":"FZPangWa-M18S"},{"ch":"方正宋一简体","en":"FZSongYi-Z13S"},{"ch":"方正剪纸简体","en":"FZJianZhi-M23S"},{"ch":"方正流行体简体","en":"FZLiuXingTi-M26S"},{"ch":"方正祥隶简体","en":"FZXiangLi-S17S"},{"ch":"方正粗活意简体","en":"FZCuHuoYi-M25S"},{"ch":"方正胖头鱼简体","en":"FZPangTouYu-M24S"},{"ch":"方正卡通简体","en":"FZKaTong-M19S"},{"ch":"方正艺黑简体","en":"FZYiHei-M20S"},{"ch":"方正水黑简体","en":"FZShuiHei-M21S"},{"ch":"方正古隶简体","en":"FZGuLi-S12S"},{"ch":"方正幼线简体","en":"FZYouXian-Z09S"},{"ch":"方正启体简体","en":"FZQiTi-S14S"},{"ch":"方正小篆体","en":"FZXiaoZhuanTi-S13T"},{"ch":"方正硬笔楷书简体","en":"FZYingBiKaiShu-S15S"},{"ch":"方正毡笔黑简体","en":"FZZhanBiHei-M22S"},{"ch":"方正硬笔行书简体","en":"FZYingBiXingShu-S16S"}]}
// 数据
var arrFont = dataFont['windows'].concat(dataFont['OS X'], dataFont['office'], dataFont['open']);
var option = '';
arrFont.forEach(function (obj) {
    var fontFamily = obj.en;
    if (isSupportFontFamily(fontFamily)) {
        option = option + '<option value="'+ fontFamily +'">'+ obj.ch +'</option>';
    }
});
eleSelect.innerHTML = option;
// 事件
eleSelect.addEventListener('change', function () {
    eleTarget.style.fontFamily = eleSelect.value;
});
// 首次匹配
eleTarget.style.fontFamily = eleSelect.value;

<select id="select">
    <option>请选择</option>
</select>
<p id="target">　　唐门外门弟子唐三21e514862ed5b9aa5d23，因偷学内门绝学为唐门所不容，跳崖明志时却发现没有死，反而以另外一个身份来到了另一个世界，一个属于武魂的世界，名叫斗罗大陆。这里没有魔法，没有斗气，没有武术，却有神奇的武魂。这里的每个人，在自己六岁的时候，都会在武魂殿中令武魂觉醒。武魂有动物，有植物，有器物，武魂可以辅助人们的日常生活。而其中一些特别出色的武魂却可以用来修炼并进行战斗，这个职业，是斗罗大陆上最为强大也是最荣耀的职业——魂师!<br>　　当唐门暗器来到斗罗大陆，当唐三武魂觉醒，他能否在这片武魂的世界再铸唐门的辉煌？他能否成为这个世界的主宰：神?</p>